A pentadecapeptide with diverse biological activities
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BPC 157 (acetate)

Item No. 30989

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-α-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-α-aspartyl-L-α-aspartyl-L-alanylglycyl-L-leucyl-L-valine, acetate
CAS Number
1628202-19-6
Synonyms
  • GEPPPGKPADDAGLV
  • Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula
C62H98N16O22 • XC2H4O2
Formula Weight
1419.5
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
C[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@H]2N(C([C@@H]3CCCN3C([C@@H]4CCCN4C([C@@H](NC(CN)=O)CCC(O)=O)=O)=O)=O)CCC2)=O)=O)CCCCN)=O)=O.CC(O)=OC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)NC([C@@H]1CCCN1C([C@@H](NC(CNC([C@H]2N(C([C@@H]3CCCN3C([C@@H]4CCCN4C([C@@H](NC(CN)=O)CCC(O)=O)=O)=O)=O)CCC2)=O)=O)CCCCN)=O)=O.CC(O)=O
InChi Code
InChI=1S/C62H98N16O22.C2H4O2/c1-31(2)25-37(55(92)74-50(32(3)4)62(99)100)71-46(81)29-65-51(88)33(5)67-53(90)38(26-48(84)85)73-54(91)39(27-49(86)87)72-52(89)34(6)68-57(94)41-15-10-21-75(41)58(95)35(13-7-8-20-63)70-45(80)30-66-56(93)40-14-9-22-76(40)60(97)43-17-12-24-78(43)61(98)42-16-11-23-77(42)59(96)36(18-19-47(82)83)69-44(79)28-64;1-2(3)4/h31-43,50H,7-30,63-64H2,1-6H3,(H,65,88)(H,66,93)(H,67,90)(H,68,94)(H,69,79)(H,70,80)(H,71,81)(H,72,89)(H,73,91)(H,74,92)(H,82,83)(H,84,85)(H,86,87)(H,99,100);1H3,(H,3,4)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,50-;/m0./s1
InChi Key
LIKSGLHWFDSWDW-OIBXLTBVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Body protection compound 157 (BPC 157) is a pentadecapeptide fragment of BPC that has been found in gastric juice and has diverse biological activities.1 It increases cell migration of, and F-actin formation in, primary rat tendon fibroblasts when used at a concentration of 2 µg/ml.2 BPC 157 (0.01 and 10 µg/kg, i.p.) reduces paw swelling, bone erosion, and inflamed joint mononuclear cell infiltration in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant (CFA).3 It decreases the lesion size of gastric ulcers induced by indomethacin (Item No. 70270), aspirin (Item No. 70260), or diclofenac (Item Nos. 70680 | 22983) in rats at the same doses. BCP 157 (0.01 and 10 µg/kg, i.p.) decreases the duration of catalepsy and reduces tremor severity in a mouse model of Parkinson's disease induced by MPTP.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sikiric, P., Seiwerth, S., Rucman, R., et al. Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications. Curr. Neuropharmacol. 14(8), 857-865 (2016).

    2. Chang, C.-H., Tsai, W.-C., Lin, M.-S., et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J. Appl. Physiol. 110(3), 774-780 (2011).

    3. Sikiric, P., Seiwerth, S., Grabarevic, Z., et al. Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats. J. Physiol. (Paris) 91(3-5), 113-122 (1997).

    4. Sikiric, P., Marovic, A., Matoz, W., et al. A behavioural study of the effect of pentadecapeptide BPC 157 in Parkinson’s disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Physiol. (Paris) 93(6), 505-512 (1999).