A reversible inhibitor of pantothenate kinase
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Pantothenate Kinase Inhibitor

Item No. 31002

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dimethyl-N-[3-(methylthio)phenyl]-pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine-3-propanamide
CAS Number
902614-04-4
Synonyms
  • PANKi
  • PanK Inhibitor
Molecular Formula
C21H21N5OS
Formula Weight
391.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.25 mg/ml
λmax
233, 282 nm
SMILES
CC1=C(CCC(NC2=CC=CC(SC)=C2)=O)C(C)=NC3=C(C=CC=N4)C4=NN31
InChi Code
InChI=1S/C21H21N5OS/c1-13-17(9-10-19(27)24-15-6-4-7-16(12-15)28-3)14(2)26-21(23-13)18-8-5-11-22-20(18)25-26/h4-8,11-12H,9-10H2,1-3H3,(H,24,27)
InChi Key
UNCZUEUPSJKHGB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Pantothenate Kinase Inhibitor (PANKi) is a reversible inhibitor of pantothenate kinase (PanK; IC50s = 70, 92, and 25 nM for PanK1β, PanK2, and PanK3, respectively), the rate-limiting enzyme in the synthesis of coenzyme A (CoA; Item Nos. 16147 | 21499 | 21722).1 It binds to the ATP-PanK3 complex with an apparent binding constant of 300 nM and exhibits mixed-type inhibition with respect to ATP and pantothenate. PANKi inhibits CoA biosynthesis in C3A cells (IC50 = 0.9 µM) with no effect on cell viability when used at concentrations up to 8 µM. PANKi (5 µM) synergizes with BSO to induce ferroptosis in PANC-1 cells and sensitizes the cells to imidazole ketone erastin-induced ferroptosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharma, L.K., Leonardi, R., Lin, W., et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J. Med. Chem. 58(3), 1563-1568 (2015).

    2. Badgley, M.A., Kremer, D.M., Maurer, H.C., et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science 368(6486), 85-89 (2020).