An allosteric activator of SERCA2
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CDN1163

Item No. 31123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-benzamide
CAS Number
892711-75-0
Molecular Formula
C20H20N2O2
Formula Weight
320.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
SMILES
CC(C=C1)=NC2=C1C=CC=C2NC(C3=CC=C(OC(C)C)C=C3)=O
InChi Code
InChI=1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)
InChi Key
GVGVYDCVFBGALZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $203

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    25 mg

    $336

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    Cayman Chemical
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    Product Description

    CDN1163 is an allosteric activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) that enhances calcium uptake in endoplasmic reticulum (ER) vesicles when used at concentrations ranging from 1 to 10 µM.1 It decreases peroxide-induced cell death in HEK293 cells. CDN1163 (50 mg/kg) increases calcium uptake in ER microsomes isolated from obese mouse liver. It decreases blood glucose levels, plasma and hepatic triglyceride levels, and plasma cholesterol and malondialdehyde (MDA) levels in obese mice. CDN1163 (50 mg/kg) restores SERCA activity, prevents gastrocnemius muscle loss and contractile dysfunction, and reduces mitochondrial production of reactive oxygen species (ROS) in the CuZnSOD-deficient (Sod-/-) mouse model of oxidative stress-related muscle atrophy and weakness.2 It also improves motor deficits in the initiation time (IT), stepping, and cylinder tests for akinesia in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kang, S., Dahl, R., Hsieh, W., et al. Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. The Journal of Biological Chemisty 291(10), 5185-5198 (2016).

    2. Qaisar, R., Bhaskaran, S., Ranjit, R., et al. Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness. Redox Biol. 20, 68-74 (2019).

    3. Dahl, R. A new target for Parkinson’s disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg. Med. Chem. 25(1), 53-57 (2017).