An internal standard for the quantification of desethyl hydroxychloroquine
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Unlabeled Version(s)
31152Desethyl Hydroxychloroquine
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Desethyl Hydroxychloroquine-d4

Item No. 31162

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]amino]-ethan-1,1,2,2-d4-ol
CAS Number
1854126-47-8
Synonyms
  • Cletoquine-d4
  • (±)-Desethylhydroxychloroquine-d4
  • DHCQ-d4
Molecular Formula
C16H18ClD4N3O
Formula Weight
311.8
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleMethanol: Soluble
SMILES
ClC1=CC2=C(C=C1)C(NC(C)CCCNC([2H])([2H])C([2H])([2H])O)=CC=N2
InChi Code
InChI=1S/C16H22ClN3O/c1-12(3-2-7-18-9-10-21)20-15-6-8-19-16-11-13(17)4-5-14(15)16/h4-6,8,11-12,18,21H,2-3,7,9-10H2,1H3,(H,19,20)/i9D2,10D2
InChi Key
XFICNUNWUREFDP-YQUBHJMPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Desethyl hydroxychloroquine-d4 is intended for use as an internal standard for the quantification of desethyl hydroxychloroquine (Item No. 31152) by GC- or LC-MS. Desethyl hydroxychloroquine is an active metabolite of hydroxychloroquine (Item No. 17911).1 It is formed via the desethylation of hydroxychloroquine in the liver, a process mediated by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP3A5, and CYP2C8.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Charlier, B., Pingeon, M., Dal Piaz, F., et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed. Chromatogr. 32(8), e4258 (2018).