An internal standard for the quantification of aflatoxin B1
Related Products
Unlabeled Version(s)
11293Aflatoxin B1
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Aflatoxin B1-13C17

Item No. 31260

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6aR,9aS)-4-(methoxy-13C)-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione-1,2,3,3a,3b,4,5,5a,6a,8,9,9a,9b,9c,11,11a-13C16
CAS Number
1217449-45-0
Synonyms
  • AFB1-13C17
Molecular Formula
[13C]17H12O6
Formula Weight
329.1
Purity
≥98%
Formulation
A 0.5 µg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
O=[13C]1[13C]2=[13C]([13CH2][13CH2][13C]2=O)[13C]3=[13C]([13C]([13C@@]([13CH]=[13CH]O4)([H])[13C@@]4([H])O5)=[13C]5[13CH]=[13C]3O[13CH3])O1
InChi Code
InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1,11+1,12+1,13+1,14+1,15+1,16+1,17+1
InChi Key
OQIQSTLJSLGHID-DENWKYDXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Aflatoxin B1-13C17 (AFB1-13C17) is intended for use as an internal standard for the quantification of AFB1 (Item No. 11293) by GC- or LC-MS. AFB1 is a genotoxic mycotoxin that has been found in Aspergillus.1,2 It induces the formation of DNA adducts in rat liver microsomes.1 AFB1 induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells.2 In vivo, AFB1 (50 and 100 µg/kg) induces hepatocellular carcinoma tumor formation in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Essigmann, J.M., Croy, R.G., Nadzan, A.M., et al. Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro. Proc. Natl. Acad. Sci. USA 74(5), 1870-1874 (1977).

    2. Aguilar, F., Hussain, S.P., and Cerutti, P. Aflatoxin B1 induces the transversion of G -> T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA 90(18), 8586-8590 (1993).

    3. Wogan, G.N., Paglialunga, S., and Newberne, P.M. Carcinogenic effects of low dietary levels of aflatoxin B1 in rats. Fd. Cosmet. Toxicol. 12(5-6), 681-685 (1974).