A genotoxic mycotoxin
Related Products
Active Metabolite(s)
11297Aflatoxin M1 20437Aflatoxin R0
Labeled Version(s)
31260Aflatoxin B1-13C17
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Aflatoxin B1

Item No. 11293

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,6aR,9aS-tetrahydro-4-methoxy-1H,11H-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione
CAS Number
1162-65-8
Synonyms
  • AFB1
  • HSDB 3453
  • NSC 529592
Molecular Formula
C17H12O6
Formula Weight
312.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 12 mg/ml
λmax
223, 265, 360 nm
SMILES
O=C1C2=C(CCC2=O)C3=C(C(C(C=CO4)C4O5)=C5C=C3OC)O1
InChi Code
InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3
InChi Key
OQIQSTLJSLGHID-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $54

    Add

    5 mg

    $216

    Add

    10 mg

    $378

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Aflatoxin B1 (AFB1) is a genotoxic mycotoxin that has been found in Aspergillus.1,2 It induces the formation of DNA adducts in rat liver microsomes.1 AFB1 induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells.2 In vivo, AFB1 (50 and 100 µg/kg) induces hepatocellular carcinoma tumor formation in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Essigmann, J.M., Croy, R.G., Nadzan, A.M., et al. Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro. Proc. Natl. Acad. Sci. USA 74(5), 1870-1874 (1977).

    2. Aguilar, F., Hussain, S.P., and Cerutti, P. Aflatoxin B1 induces the transversion of G -> T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA 90(18), 8586-8590 (1993).

    3. Wogan, G.N., Paglialunga, S., and Newberne, P.M. Carcinogenic effects of low dietary levels of aflatoxin B1 in rats. Fd. Cosmet. Toxicol. 12(5-6), 681-685 (1974).