A phenylpropanoid with diverse biological activities
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Isomer(s)
29862(E)-Anethol29824Estragole
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Anethol

Item No. 31398

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methoxy-4-(1-propen-1-yl)-benzene
CAS Number
104-46-1
Synonyms
  • p-Propenylanisole
  • p-Anthole
  • NSC 4018
Molecular Formula
C10H12O
Formula Weight
148.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
258 nm
SMILES
CC=CC(C=C1)=CC=C1OC
InChi Code
InChI=1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3-8H,1-2H3
InChi Key
RUVINXPYWBROJD-UHFFFAOYSA-N
Origin
Plant/Illicium verum
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $75

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    1 g

    $143

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    5 g

    $442

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    10 g

    $662

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    Product Description

    Anethol is a phenylpropanoid that has been found in anise and fennel oils and has diverse biological activities.1,2,3,4 It decreases the production of reactive oxygen species (ROS) in and increases survival of primordial follicles in isolated goat ovarian fragments when used at a concentration of 30 µg/ml.1 Anethol (62.5, 125, and 250 mg/kg) reduces paw swelling and the number of serum and synovial leukocytes, as well as prevents joint cartilage destruction in a rat model of adjuvant-induced arthritis.2 It reduces TNF-α production in a rat model of LPS-induced periodontitis.3 Anethol (125, 250, and 500 mg/kg) attenuates mechanical and thermal hyperalgesia in a mouse model of neuropathic pain induced by chronic constriction injury (CCI).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sà, N.A.R., Bruno, J.B., Guerrerio, D.D., et al. Anethole reduces oxidative stress and improves in vitro survival and activation of primordial follicles. Braz. J. Med. Biol. Res. 51(8), e7129 (2018).

    2. Ritter, A.M.V., Hernandes, L., da Rocha, B.A., et al. Anethole reduces inflammation and joint damage in rats with adjuvant-induced arthritis. Inflamm. Res. 66(8), 725-737 (2017).

    3. Aprotosoaie, A.C., Costache, I.-I., and Miron, A. Anethole and its role in chronic diseases. Adv. Exp. Med. Biol. 929, 247-267 (2016).

    4. Wang, B., Zhang, G., Yang, M., et al. Neuroprotective effect of anethole against neuropathic pain induced by chronic constriction injury of the sciatic nerve in mice. Neurochem. Res. 43(12), 2402-2422 (2018).