An inhibitor of ferroptosis
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RC363

Item No. 31407

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-bis(1,1-dimethylethyl)-4-(2-thienylthio)-phenol
CAS Number
2584411-86-7
Molecular Formula
C18H24OS2
Formula Weight
320.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
249 nm
SMILES
OC1=C(C(C)(C)C)C=C(SC2=CC=CS2)C=C1C(C)(C)C
InChi Code
InChI=1S/C18H24OS2/c1-17(2,3)13-10-12(21-15-8-7-9-20-15)11-14(16(13)19)18(4,5)6/h7-11,19H,1-6H3
InChi Key
NGMIDNYWQLUYJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    Product Description

    RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol (Item No. 15043).1 It reduces 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals by approximately 40% in a cell-free assay when used at a concentration of 25 µM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50 = 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT22 cells when used at a concentration of 3 µM. RC363 inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells (IC50 = 173.6 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bueno, D.C., Canto, R.F.S., de Souza, V., et al. New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cells. Mol. Neurobiol. 57(8), 3273-3290 (2020).