An internal standard for the quantification of famotidine
Related Products
Unlabeled Version(s)
23828Famotidine
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Famotidine-13C-d3

Item No. 31493

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)-propanimidamide1-13C-2,3,3-d3
CAS Number
2744683-81-4
Molecular Formula
C7[13C]H12D3N7O2S3
Formula Weight
341.5
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleMethanol: soluble
SMILES
NS(N[13C](C([2H])C([2H])([2H])SCC1=CSC(NC(N)=N)=N1)=N)(=O)=O
InChi Code
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)/i1D,2D2,6+1
InChi Key
XUFQPHANEAPEMJ-DTTOTARQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $575

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    Product Description

    Famotidine-13C-d3 is intended for use as an internal standard for the quantification of famotidine (Item No. 23828) by GC- or LC-MS. Famotidine is a histamine H2 receptor antagonist with a Ki value of 12 nM in fractionated guinea pig cerebral cortex membranes.1 It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex).2 Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6 µM).3 It also suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400 µg/kg, respectively).3 Formulations containing famotidine have been used in the treatment of ulcers, gastroesophageal reflux disease (GERD), and heartburn, as well as to decrease the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gajtkowski, G.A., Norris, D.B., Rising, T.J., et al. Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex. Nature 304(5921), 65-67 (1983).

    2. Kubo, N., Shirakawa, S., Kuno, T., et al. Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assay. Jpn. J. Pharmacol. 43(3), 277-282 (1987).

    3. Nagaya, H., Inatomi, N., and Satoh, H. Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogs. Jpn. J. Pharmacol. 55(4), 425-436 (1991).