A TXNIP inhibitor
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SRI-37330

Item No. 31638

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[1-[6-(trifluoromethyl)-4-quinazolinyl]-3-piperidinyl]methyl]-methanesulfonamide
CAS Number
2322245-42-9
Molecular Formula
C16H19F3N4O2S
Formula Weight
388.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleWater: Slightly soluble
SMILES
FC(F)(F)C1=CC=C(N=CN=C2N3CC(CNS(C)(=O)=O)CCC3)C2=C1
InChi Code
InChI=1S/C16H19F3N4O2S/c1-26(24,25)22-8-11-3-2-6-23(9-11)15-13-7-12(16(17,18)19)4-5-14(13)20-10-21-15/h4-5,7,10-11,22H,2-3,6,8-9H2,1H3
InChi Key
WRSNFEVXRKOMLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $145

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    10 mg

    $256

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    25 mg

    $559

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    SRI-37330 is an inhibitor of thioredoxin-interacting protein (TXNIP).1 It inhibits the expression of Txnip mRNA in INS-1 rat insulinoma cells (IC50 = 0.64 µM) and decreases Txnip protein levels in the same cells in a concentration-dependent manner. SRI-37330 (10 µM) inhibits LPS-induced pyroptosis in A549 cells overexpressing fat mass and obesity-associated (FTO) protein in an in vitro model of acute lung injury.2 In vivo, SRI-37330 (100 mg/kg) reduces non-fasting and fasting blood glucose levels, serum glucagon levels, and hepatic glucose production in wild-type and db/db mice.1 It also decreases non-fasting blood glucose levels, urinary glucose levels, and serum triglyceride levels in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thielen, L.A., Chen, J., Jing, G., et al. Identification of an anti-diabetic, orally available small molecule that regulates TXNIP expression and glucagon action. Cell Metab. 32(3), 353-365.e358 (2020).

    2. Xie, W.-M., Su, W., Liu, X.-Y., et al. FTO deficiency alleviate LPS-induced ALI by TXNIP/NLPR3-mediated alveolar epithelial cell pyroptosis. Am. J. Respir. Cell Mol. Biol. (2024).