SCF Extracellular Domain (human, recombinant)

Stem cell factor (SCF), also known as steel factor or c-Kit ligand, is a growth factor and cytokine that promotes proliferation, migration, survival, and differentiation of hematopoietic progenitors, germ cells, and melanocytes and is encoded by KITLG in humans.¹ It is composed of an extracellular domain that contains a c-Kit binding region, a transmembrane domain, and a C-terminal intracellular tail and is ubiquitously expressed by fibroblasts and endothelial cells. SCF also exists as a soluble form produced by proteolytic cleavage of a membrane-bound isoform of SCF produced by alternative splicing and lacking exon 6. Both membrane-bound and soluble SCF homodimerize and bind to the SCF receptor, also known as c-Kit, to induce intracellular signaling. Allergen exposure increases lung and serum levels of SCF in a mouse model of allergic inflammation, and airway levels of SCF are increased in patients with asthma.² Exogenous administration of SGF decreases infarct size and improves motor function in a spontaneously hypertensive rat model of stroke induced by middle cerebral artery occlusion.³ SCF inhibits apoptosis of CD34⁺ acute myeloid leukemia cells induced by cytarabine (Item No. 16069), daunorubicin (Item No. 14159), or carboplatin (Item No. 13112).⁴ Cayman's SCF Extracellular Domain (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 175 amino acids, has a calculated molecular weight of 19.9 kDa, and a predicted N-terminus of Glu26 after signal peptide cleavage.

WARNING This product is not for human or veterinary use.

1. Lennartsson, J., and Rönnstrand, L. Stem cell factor receptor/c-Kit: From basic science to clinical implications. Physiol. Rev. 92(4), 1619-1649 (2012).

2. Silva, C.A.D., Reber, L., and Frossard, N. Stem cell factor expression, mast cells and inflammation in asthma. Fundam. Clin. Pharmacol. 20(1), 21-39 (2006).

3. Zhao, L.R., Piao, C.S., Murikinati, S.R., et al. The role of stem cell factor and granulocyte-colony stimulating factor in treatment of stroke. Recent Pat. CNS Drug Discov. 8(1), 2-12 (2013).

4. Hassan, H.T., and Zander, A. Stem cell factor as a survival and growth factor in human normal and malignant hematopoiesis. Acta Haematol. 95(3-4), 257-262 (1996).