For immunochemical detection of H3K23Ac
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Histone H3K23Ac Monoclonal Antibody (RM169)

Item No. 32161

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Acetylated Histone H3 Lysine 23
Immunogen
Peptide corresponding to H3K23Ac
Clone Designation
RM169
Formulation (Request formulation change)
100 µg of protein A affinity-purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA, ICC, multiplex-based assays, WB
Cross Reactivity
(+) H3K23Ac(-) Unmodified H3K23(-) H3K4Ac(-) H3K9Ac(-) H3K14Ac(-) H3K18Ac(-) H3K27Ac(-) H3K36Ac(-) H3K56Ac(-) H3K79Ac(-) H3K122Ac
Species Reactivity
(+) Vertebrates
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $500

    Add
    Cayman Chemical
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    Product Description

    Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.1,2 Acetylation of histone H3 at lysine 23 (H3K23Ac) is associated with transcriptional activation.3,4 Levels of H3K23Ac are decreased in control, but increased in uninephrectomized, db/db diabetic mouse kidney compared with wild-type mouse kidney.5 Cayman's Histone H3K23Ac Monoclonal Antibody (RM169) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyun, K., Jeon, J., Park, K., et al. Writing, erasing and reading histone lysine methylations. Exp. Mol. Med. 49(4), e324 (2017).

    2. Sharda, A., Amnekar, R.V., Natu, A., et al. Histone posttranslational modifications: Potential role in diagnosis, prognosis, and therapeutics of cancer. Prognostic Epigenetics 15, 351-373 (2019).

    3. Keating, S.T., van Diepen, J.A., Risken, N.P., et al. Epigenetics in diabetic nephropathy, immunity and metabolism. Diabetologia 61(1), 6-20 (2018).

    4. Nakanishi, S., Sanderson, B.W., Delventhal, K.M., et al. A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation. Nat. Struct. Mol. Biol. 15(8), 881-888 (2008).

    5. Sayyed, S.G., Gaikwad, A.B., Lichtnekert, J., et al. Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10. Nephrol. Dial. Transplant. 25(6), 1811-1817 (2010).