OX40/CD134 (C-Term) Rabbit Monoclonal Antibody (Clone RM313)

OX40, also known as TNF receptor superfamily member 4 (TNFRSF4), is a type I transmembrane glycoprotein and the cognate receptor for the T cell co-stimulatory molecule OX40L (TNFSF4; Item No. 32065).¹ OX40 assembles into trimers, with each monomer containing three cysteine-rich domains (CRDs) that bind OX40L and a cytoplasmic tail that interacts with TNF receptor-associated factor 1 (TRAF1), -2, -3, and -5 to induce a variety of intracellular signaling cascades, including NF-κB, ERK, PI3K, and Akt pathways.^2,1 OX40 is transiently expressed on CD4⁺ and CD8⁺ T cells in response to antigen stimulation in humans and is localized to lipid rafts.^3,1 Binding of an OX40 trimer to trimeric OX40L, expressed by antigen-presenting cells (APCs), including dendritic cells (DCs), macrophages, and B cells, forms a hexameric OX40-OX40L complex that promotes effector T cell phenotype and function, proliferation, survival, and memory.³ Increased OX40 levels have been found in inflamed tissues isolated from patients with a variety of autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus (SLE), or rheumatoid arthritis.³ Cayman's OX40 (C-Term) Rabbit Monoclonal Antibody (Clone RM313) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.

1. Buchan, S.L., Rogel, A., and Al-Shamkhani, A. The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood 131(1), 39-48 (2018).

2. Croft, M., So, T., Duan, W., et al. The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1), 173-191 (2009).

3. Webb, G.J., Hirschfield, G.M., and Lane, P.J.L. OX40, OX40L and autoimmunity: A comprehensive review. Clin. Rev. Allergy Immunol. 50(3), 312-332 (2016).