Polyethylene Glycol Rabbit Monoclonal Antibody - Biotinylated (Clone RM105)

Polyethylene glycols (PEGs) are synthetic and hydrophilic polymers.^1,2 They are linear or branched and contain a reactive end group, such as acrylate, methacrylate, dibenzocyclooctynol, or vinyl sulfonate, for covalent attachment to macromolecules or linkers. The opposite end group of PEGs is commonly a methyl group (methoxy PEG), however, hydroxy, amino, butoxy, and tert-butoxy end groups have also been used.¹ PEGs are non-toxic and are commonly used to prolong the in vivo circulation time of pharmaceutical agents.² Free PEGs are non-immunogenic but become immunogenic when conjugated to a drug delivery nanosystem (DDS) or a macromolecule.¹ Immunogenicity of PEGs varies based on polymer length and branching, end group composition, and chemical nature of the PEG acceptor structure. Cayman’s Polyethylene Glycol Rabbit Monoclonal Antibody - Biotinylated (Clone RM105) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes PEGs containing a methoxy end group.

WARNING This product is not for human or veterinary use.

1. Kozma, G.T., Shimizu, T., Ishida, T., et al. Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals. Adv. Drug Deliv. Rev. 154-155, 163-175 (2020).

2. Zhang, Z., Zhang, Y., Song, S., et al. Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals. J. Sep. Sci. 43(9-10), 1978-1997 (2020).