An LSD1 inhibitor
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CC-90011

Item No. 32727

Product Insert (PDF)
Technical Information
Formal Name
4-[2-(4-amino-1-piperidinyl)-5-(3-fluoro-4-methoxyphenyl)-1,6-dihydro-1-methyl-6-oxo-4-pyrimidinyl]-2-fluoro-benzonitrile, monobenzenesulfonate
CAS Number
2097523-60-7
Synonyms
  • LSD1-IN-7
  • LSD1 Inhibitor 7
  • Lysine-specific Demethylase 1-IN-7
  • Lysine-specific Demethylase 1 Inhibitor 7
Molecular Formula
C24H23F2N5O2 • C6H6O3S
Formula Weight
609.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
N#CC1=CC=C(C(N=C(N2CCC(CC2)N)N3C)=C(C4=CC(F)=C(OC)C=C4)C3=O)C=C1F.O=S(O)(C5=CC=CC=C5)=O
InChi Code
InChI=1S/C24H23F2N5O2.C6H6O3S/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31;7-10(8,9)6-4-2-1-3-5-6/h3-6,11-12,17H,7-10,28H2,1-2H3;1-5H,(H,7,8,9)
InChi Key
AWZCBGWZNHQCIZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    CC-90011 is an inhibitor of lysine-specific demethylase 1 (LSD1; IC50 = 0.3 nM).1 It is selective for LSD1 over LSD2, monoamine oxidase A (MAO-A), and MAO-B at 10 µM. CC-90011 induces differentiation in THP-1 cells (EC50 = 7 nM) and inhibits the proliferation of NCI H1417 small cell lung cancer (SCLC) cells (EC50 = 6 nM). It also inhibits lipid accumulation induced by palmitic acid (Item No. 10006627) and oleic acid (Item Nos. 90260 | 24659) in Huh7 hepatocytes when used at a concentration of 20 µM.2 In vivo, CC-90011 (2.5 mg/kg) reduces tumor volume in an NCI H1417 mouse xenograft model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kanouni, T., Severin, C., Cho, R.W., et al. Discovery of CC-90011: A potent and selective reversible inhibitor of lysine specific demethylase 1 (LSD1). J. Med. Chem. 63(23), 14522-14529 (2020).

    2. Yang, Z., Zhang, S., Liu, X., et al. Histone demethylase KDM1A promotes hepatic steatosis and inflammation by increasing chromatin accessibility in NAFLD. J. Lipid Res. 65(3), 100513 (2024).