A CXCR2 antagonist
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SB-332235

Item No. 32869

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxy-benzenesulfonamide
CAS Number
276702-15-9
Molecular Formula
C13H10Cl3N3O4S
Formula Weight
410.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(NC1=CC=C(C(S(N)(=O)=O)=C1O)Cl)NC2=C(Cl)C(Cl)=CC=C2
InChi Code
InChI=1S/C13H10Cl3N3O4S/c14-6-2-1-3-8(10(6)16)18-13(21)19-9-5-4-7(15)12(11(9)20)24(17,22)23/h1-5,20H,(H2,17,22,23)(H2,18,19,21)
InChi Key
WTLRWOHEKQGKDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $190

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    10 mg

    $283

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    25 mg

    $587

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    Cayman Chemical
    Neutrophil Biology Wall Poster

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    Product Description

    SB-332235 is an antagonist of chemokine (C-X-C motif) receptor 2 (CXCR2; IC50 = 9.3 nM in CHO cell membranes expressing the recombinant human receptor).1 It is selective for CXCR2 over CXCR1 (IC50 = 9,633 nM). SB-332235 (10 ng/ml) inhibits migration of isolated human peripheral blood monocytes induced by chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL5, or CXCL8 by 92, 73, and 50%, respectively.2 It decreases cigarette smoke-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration when administered at a dose of 1 mg/kg.3 SB-332235 (1 mg/kg) reduces increases in neuronal levels of 4-hydroxy nonenal (4-HNE; Item No. 32100) induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in a rat model of Alzheimer's disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Podolin, P.L., Bolognese, B.J., Foley, J.J., et al. A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J. Immunol. 169(11), 6435-6444 (2002).

    2. Traves, S.L., Smith, S.J., Barnes, P.J., et al. Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: A role for CXCR2. J. Leukoc. Biol. 76(2), 441-450 (2004).

    3. Stevenson, C.S., Coote, K., Webster, R., et al. Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. Am. J. Physiol. Lung Cell. Mol. Physiol. 288(3), L514-L522 (2005).

    4. Ryu, J.K., Cho, T., Choi, H.B., et al. Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease. J. Neuroinflammation 12, 144 (2015).