A lignan with diverse biological activities
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Sesamol

Item No. 32903

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-benzodioxol-5-ol
CAS Number
533-31-3
Synonyms
  • NSC 59256
Molecular Formula
C7H6O3
Formula Weight
138.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
OC1=CC=C2OCOC2=C1
InChi Code
InChI=1S/C7H6O3/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3,8H,4H2
InChi Key
LUSZGTFNYDARNI-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $36

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    25 g

    $81

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    50 g

    $153

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    100 g

    $288

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Sesamol is a lignan originally isolated from S. indicum that has diverse biological activities, including antioxidant, antibacterial, anticancer, and anti-obesity properties.1,2,3,4 Sesamol scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an IC50 value of 5.44 μg/ml and is active against B. cereus and S. aureus (MICs = 2 mg/ml for both).2 It also inhibits the growth of HepG2 human hepatocellular carcinoma cells in a concentration-dependent manner.3 Sesamol (100 mg/kg) reduces weight gain and hepatic steatosis in a mouse model of obesity induced by a high-fat diet (HFD).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Majdalawieh, A.F., and Mansour, Z.R. Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action. Eur. J. Pharmacol. 855, 75-89 (2019).

    2. Kumar, C.M., and Singh, S.A. Bioactive lignans from sesame (Sesamum indicum L.): Evaluation of their antioxidant and antibacterial effects for food applications. J. Food Sci. Technol. 52(5), 2934-2941 (2015).

    3. Liu, Z., Ren, B., Wang, Y., et al. Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy. Sci. Rep. 7, 5728 (2017).

    4. Lee, D.H., Chang, S.-H., Yang, D.-K., et al. Sesamol increases Ucp1 expression in white adipose tissues and stimulates energy expenditure in high-fat diet-fed obese mice. Nutrients 12(5), 1459 (2020).