Sparstolonin B

Sparstolonin B is an isocoumarin that has been found in Spaganium stoloniferum and has diverse biological activities.^1,2,3,4 It inhibits increases in TNF-α, IL-6, and IL-1β levels induced by the toll-like receptor 4 (TLR4) agonist LPS, TLR2 agonist Pam₃CSK₄ (Item No. 24126), or TLR2/6 agonist FSL-1 (Item No. 24220) but not the TLR3 agonist poly(I:C) or TLR9 agonist ODN1668 in primary mouse macrophages when used at a concentration of 100 µM.¹ Sparstolonin B (1-10 µM) reduces HIV-1 p24 antigen levels in the culture supernatant of human peripheral blood mononuclear cells (PBMCs) infected with HIV-1, indicating inhibition of HIV replication.² It induces apoptosis, cell cycle arrest at the G₂/M phase, and production of reactive oxygen species (ROS) in SH-SY5Y neuroblastoma cells when used at a concentration of 10 µM.³ Sparstolonin B (3 and 9 mg/kg) protects mice from lethal endotoxin shock.⁴

WARNING This product is not for human or veterinary use.

1. Liang, Q., Wu, Q., Jiang, J., et al. Characterization of sparstolonin B, a chinese herb-derived compound, as a selective toll-like receptor antagonist with potent anti-inflammatory properties. The Journal of Biological Chemisty 286(30), 26470-26479 (2011).

2. Deng, X., Zhang, Y., Jiang, F., et al. The chinese herb-derived sparstolonin B suppresses HIV-1 transcription. Virol. J. 12, 108 (2015).

3. Kumar, A., Fan, D., Dipette, D.J., et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells. PLoS One 9(5), e96343 (2014).

4. Liang, Q., Dong, S., Lei, L., et al. Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock. Cytokine 75(2), 302-309 (2015).