Marein

Marein is a glucoside chalcone that has been found in C. tinctoria and has diverse biological activities, including antioxidant, enzyme inhibitory, antidiabetic, and anti-inflammatory properties.^1,2,3 It scavenges DPPH (Item No. 14805) radicals (IC₅₀ = 48.35 μM) in a cell-free assay and is an inhibitor of EGFR (IC₅₀ = 19.94 μM).^1,2 Marein (50 mg/kg) reduces fasting blood glucose and fasting serum levels of insulin, triglycerides, LDL cholesterol, and total cholesterol in diabetic db/db mice.³ It also reduces serum and renal IL-6 and chemokine (C-C motif) ligand 2 (CCL2) levels, as well as decreases kidney fibrosis, in db/db mice.

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1. Wang, W., Chen, W., Yang, Y., et al. New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i-converting enzyme inhibitory activities. J. Agric. Food Chem 63(1), 200-207 (2015).

2. Yang, E.B., Guo, Y.J., Zhang, K., et al. Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivatives. Biochim Biophys Acta. 1550(2), 144-152 (2001).

3. Guo, Y., Ran, Z., Zhang, Y., et al. Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cells. Biomed. Pharmacother. 131, 110684 (2020).