A metabolite of 17α-hydroxyprogesterone
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Parent Compound(s)
3315417α-Hydroxyprogesterone
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Pregnanetriol

Item No. 33312

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-pregnane-3α,17,20S-triol
CAS Number
1098-45-9
Synonyms
  • NSC 52760
  • 5β-Pregnane-3α,17α,20α-triol
Molecular Formula
C21H36O3
Formula Weight
336.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
C[C@@]12[C@](CC[C@]2(O)[C@H](C)O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
InChi Code
InChI=1S/C21H36O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h13-18,22-24H,4-12H2,1-3H3/t13-,14+,15+,16+,17-,18-,19-,20-,21-/m0/s1
InChi Key
SCPADBBISMMJAW-UHHUKTEYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $219

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    25 mg

    $336

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    Product Description

    Pregnanetriol is a metabolite of 17α-hydroxyprogesterone (Item No. 33154).1,2 It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2 Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kamrath, C., Hartmann, M.F., Boettcher, C., et al. Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infants. J. Steroid Biochem. Mol. Biol. 156, 10-16 (2016).

    2. Schiffer, L., Barnard, L., Baranowski, E.S., et al. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. J. Steroid Biochem. Mol. Biol. 194, 105439 (2019).

    3.  Disorders of steroidogenesis guide to steroid profiling and biochemical diagnosis. 1, (2019).

    4. Shackleton, C.H.L. Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesis. Lipids 47(1), 1-12 (2012).