A muscarinic acetylcholine receptor antagonist
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Alternative(s)
9002272Methylatropine (nitrate)
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Methylatropine (bromide)

Item No. 33433

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane, monobromide
CAS Number
2870-71-5
Synonyms
  • NSC 61810
Molecular Formula
C18H26NO3 • Br
Formula Weight
384.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
SMILES
O=C(C(CO)C1=CC=CC=C1)O[C@H]2C[C@H]3CC[C@H]([N+]3(C)C)C2.[Br-]
InChi Code
InChI=1S/C18H26NO3.BrH/c1-19(2)14-8-9-15(19)11-16(10-14)22-18(21)17(12-20)13-6-4-3-5-7-13;/h3-7,14-17,20H,8-12H2,1-2H3;1H/q+1;/p-1/t14-,15+,16+,17?;
InChi Key
XMLNCADGRIEXPK-KUMOIWDRSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $69

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    10 mg

    $127

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    25 mg

    $280

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    Product Description

    Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50 = <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine (Item No. 12008).1,2 It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50 value of 5.5 µg/kg.2 Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmeller, T., Sporer, F., Sauerwein, M., et al. Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors. Pharmazie 50(7), 493-495 (1995).

    2. Brezenoff, H.E., Xiao, Y.-F., and Vargas, H. A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventricles. Life Sci. 42(8), 905-911 (1988).

    3. Albanus, L. Central and peripheral effects of anticholinergic compounds. Acta Pharmacol. Toxicol. (Copenh) 28(4), 305-326 (1970).