An NSAID
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Product Type

Biochemicals

Research Area

Immunology & Inflammation
Allergy
Innate Immunity

Cicloprofen

Item No. 33571

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-9H-fluorene-2-acetic acid
CAS Number
36950-96-6
Synonyms
  • (±)-Cicloprofen
  • α-Methylfluorene-2-acetic Acid
  • NSC 293916
  • SQ 20,824
Molecular Formula
C16H14O2
Formula Weight
238.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 20 mg/ml
SMILES
O=C(C(C)C1=CC=C2C3=C(CC2=C1)C=CC=C3)O
InChi Code
InChI=1S/C16H14O2/c1-10(16(17)18)11-6-7-15-13(8-11)9-12-4-2-3-5-14(12)15/h2-8,10H,9H2,1H3,(H,17,18)
InChi Key
LRXFKKPEBXIPMW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
    Neutrophil Biology Wall Poster

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    Product Description

    Cicloprofen is a non-steroidal anti-inflammatory drug (NSAID).1,2 It inhibits histamine release induced by ragweed, A23187 (Item No. 11016), or concanavalin A (Item No. 14951) in isolated human leukocytes when used at a concentration of 0.5 mM.1 Cicloprofen inhibits carrageenan-induced paw edema in rats (ED50 = 67 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hearn, T., and Wojnar, R.J. Characterization of augmentation of allergic and non-allergic histamine release by non-steroidal anti-inflammatory/analgesic agents. Agents Actions 11(4), 352-360 (1981).

    2. Stiller, E.T., Diassi, P.A., Gerschutz, D., et al. Synthesis and antiinflammatory activities of α-methylfluorene-2-acetic acid and related compounds. J. Med. Chem. 15(10), 1029-1032 (1972).