A metabolite of estrone
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17-Epiestriol

Item No. 33601

Technical Information
Formal Name
estra-1,3,5(10)-triene-3,16α,17α-triol
CAS Number
1228-72-4
Synonyms
  • 16α-hydroxy-17α-Estradiol
  • 16α,17α-Estriol
  • 17α-Estriol
  • 17-epi-Estriol
  • NSC 84051
Molecular Formula
C18H24O3
Formula Weight
Purity
≥95%
Formulation
A solid
Methanol: slightly soluble
SMILES
C[C@@]12[C@](C[C@H]([C@H]2O)O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C=C4CC3
InChi Code
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17-,18+/m1/s1
InChi Key
PROQIPRRNZUXQM-PNVOZDDCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    17-Epiestriol is a metabolite of estrone (Item No. 10006485).1 It is formed from estrone via a 16α-hydroxy estrone (Item No. 15208) intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding affinities of 29 and 80 compared with 17β-estradiol (Item No. 10006315).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brinton, L.A., Trabert, B., Anderson, G.L., et alSerum estrogens and estrogen metabolites and endometrial cancer risk among postmenopausal women. Cancer Epidemiol. Biomarkers Prev. 25(7), 1081-1089 (2016).