An internal standard for the quantification of clofibric acid
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Unlabeled Version(s)
21608Clofibric Acid
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Clofibric Acid-d4

Item No. 33612

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-chlorophenoxy-d4)-2-methyl-propanoic acid
CAS Number
1184991-14-7
Molecular Formula
C10H7ClD4O3
Formula Weight
218.7
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
OC(C(C)(C)OC1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)=O
InChi Code
InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)/i3D,4D,5D,6D
InChi Key
TXCGAZHTZHNUAI-LNFUJOGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $109

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    1 mg

    $207

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    5 mg

    $818

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    10 mg

    $1,525

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    Cayman Chemical
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    Product Description

    Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid (Item No. 21608) by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate (Item No. 10956).1 It is formed from clofibrate by tissue and serum esterases.2 Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats.3 It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L.4 Clofibric acid has been found in wastewater effluent.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giampietro, L., Laghezza, A., Cerchia, C., et al. Novel phenyldiazenyl fibrate analogues as PPAR α/γ/δ pan-agonists for the amelioration of metabolic syndrome. ACS Med. Chem. Lett. 10(4), 545-551 (2019).

    2. Cayen, M.N. Metabolic disposition of clofibrate. Drug Metabol. Drug Interact. 3(1 & 2), 77-103 (1980).

    3. Cayen, M.N., Ferdinandi, E.S., Greselin, E., et al. Clofibrate and clofibric acid: Comparison of the metabolic disposition in rats and dogs. J. Pharmacol. Exp. Ther. 200(1), 33-43 (1977).

    4. Saravanan, M., Karthika, S., Malarvizhi, A., et al. Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: Hematological, biochemical, ionoregulatory and enzymological responses. J. Hazard. Mater. 195, 188-194 (2011).

    5. Tixier, C., Singer, H.P., Oellers, S., et al. Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters. Environ. Sci. Technol. 37(6), 1061-1068 (2003).