An internal standard for the quantification of fenspiride
Related Products
Unlabeled Version(s)
25512Fenspiride (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Fenspiride-d5

Item No. 33711

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(phenethyl-d5)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
CAS Number
1246911-67-0
Synonyms
  • Decaspiride-d5
Molecular Formula
C15H15D5N2O2
Formula Weight
265.4
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
[2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1CCN2CCC3(OC(NC3)=O)CC2
InChi Code
InChI=1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18)/i1D,2D,3D,4D,5D
InChi Key
FVNFBBAOMBJTST-RALIUCGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $347

    Add

    5 mg

    $1,127

    Add
    Product Description

    Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride (Item No. 25512) by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID).1,2 It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from patients with lung cancer).3 It is selective for these phosphodiesterases over PDE1 and PDE2, where it provides less than 25% inhibition. Fenspiride potentiates the airway relaxant effects of isoproterenol (Item No. 15592) and sodium nitroprusside indicating an effect on cAMP and cGMP phosphodiesterases, respectively. Aerosolized fenspiride (1 mg/ml) reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 1-10 mg/ml, reduces cough induced by citric acid in a guinea pig model of cough.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rognoni, F., Marchini, F., Piacenza, G., et al. Effect of 8-N-phenethyl-1-oxa-2-oxo-3,8-diazaspiro(4,5)decane hydrochloride (decaspiride) on histamine receptors. Boll. Chim. Farm. 117(7), 397-401 (1978).

    2. Laude, E.A., Bee, D., Crambes, O., et al. Antitussive and antibronchoconstriction actions of fenspiride in guinea-pigs. Eur. Respir. J. 8(10), 1699-1704 (1995).

    3. Cortijo, J., Naline, E., Ortiz, J.L., et al. Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: Functional and biochemical study. Eur. J. Pharmacol. 341(1), 79-86 (1998).