A neonicotinoid insecticide
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Dinotefuran

Item No. 33802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N′′-methyl-N-nitro-N′-[(tetrahydro-3-furanyl)methyl]-guanidine
CAS Number
165252-70-0
Synonyms
  • 1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine
  • MTI-446
  • Nidinotefuran
Molecular Formula
C7H14N4O3
Formula Weight
202.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
270 nm
SMILES
CN/C(N[N+]([O-])=O)=N\CC1CCOC1
InChi Code
InChI=1S/C7H14N4O3/c1-8-7(10-11(12)13)9-4-6-2-3-14-5-6/h6H,2-5H2,1H3,(H2,8,9,10)
InChi Key
YKBZOVFACRVRJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Dinotefuran is a neonicotinoid insecticide.1 It is an agonist of nicotinic acetylcholine receptors (nAChRs), inducing inward currents in isolated American cockroach (P. americana) neurons with an EC50 value of 7.6 µM. Dinotefuran, alone or in combination with the metabolic inhibitors piperonyl butoxide (PB; Item No. 25820) or propargyl propyl benzenephosphonate (NIA), induces mortality in adult P. americana.2 It is lethal to insecticide-sensitive or -resistant strains of A. gambiae, C. quinquefasciatus, and A. aegypti in larval (LC50s = 0.14-0.44 mg/L) and adult (LD50s = 0.18-31.16 ng/mg) bioassays.3 Dinotefuran has been found in a variety of commercial foodstuffs, including rice, cucumber, milk, egg, and pork samples, as well as in water samples from freshwater streams.4,5 Formulations containing dinotefuran have been used in the agricultural and veterinary control of insect infestations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tan, J., Galligan, J.J., and Hollingworth, R.M. Agonist actions of neonicotinoids on nicotinic acetylcholine receptors expressed by cockroach neurons. Neurotoxicology 28(4), 829-842 (2007).

    2. Kiriyama, K., and Nishimura, K. Structural effects of dinotefuran and analogues in insecticidal and neural activities. Pest Manag. Sci. 58(7), 669-676 (2002).

    3. Corbel, V., Duchon, S., Zaim, M., et al. Dinotefuran: A potential neonicotinoid insecticide against resistant mosquitoes. J. Med. Entomol. 41(4), 712-717 (2004).

    4. Zhang, Y., Wu, X., Duan, T., et al. Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal-derived foods, soil, and water. J. Sep. Sci. 41(14), 2913-2923 (2018).

    5. Hladik, M.L., and Kolpin, D.W. First national-scale reconnaissance of neonicotinoid insecticides in streams across the USA. Environ. Chem. 13, 12-20 (2016).