An insecticide synergist
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Labeled Version(s)
39581Piperonyl Butoxide-d9
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Piperonyl Butoxide

Item No. 25820

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole
CAS Number
51-03-6
Synonyms
  • NSC 8401
  • PBO
Molecular Formula
C19H30O5
Formula Weight
338.4
Purity
≥95%
Formulation
A liquid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
CCCC1=C(COCCOCCOCCCC)C=C(OCO2)C2=C1
InChi Code
InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3
InChi Key
FIPWRIJSWJWJAI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

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    Product Description

    Piperonyl butoxide is an insecticide synergist.1,2 It inhibits cytochrome P450 (CYP) activity in western corn rootworm (D. virgifera) abdominal microsomes in a concentration-dependent manner.3 Piperonyl butoxide increases the toxicity of the pyrethroid insecticide deltamethrin (Item No. 24172) to field-collected, deltamethrin-resistant strains of the bed bug C. lectularius by 5.6- to 176-fold when used at a concentration of 50 μg/μl.2 Piperonyl butoxide also increases the toxicity of the organotin insecticide cyhexatin to fourth instar larvae of susceptible strains of the cotton leafworm S. littoralis.4 It is not toxic to the freshwater invertebrates H. azteca, C. tentans, and L. variegatus (LC50s = 530, 2,740, and 3,540 μg/L, respectively) and reduces the toxicity of the organophosphate pesticides diazinon (Item No. 23769), chlorpyrifos (Item No. 21412), and azinphos-methyl.1 Formulations containing piperonyl butoxide have been used in the control of agricultural, household, and veterinary pests.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ankley, G.T., and Collyard, S.A. Influence of piperonyl butoxide on the toxicity of organophosphate insecticides to three species of freshwater benthic invertebrates. Comp. Biochem. Physiol. 110(2), 149-155 (1995).

    2. Romero, A., Potter, M.F., and Haynes, K.F. Evaluation of piperonyl butoxide as a deltamethrin synergist for pyrethroid-resistant bed bugs. J. Econ. Entomol. 102(6), 2310-2315 (2009).

    3. Scharf, M.E., Siegfried, B.D., Meinke, L.J., et al. Cytochrome P450-mediated N-demethylation activity and induction in insecticide-resistant and susceptible western corn rootworm populations (Coleoptera: Chrysomelidae). Pesicide Biochem. Physiol. 67(2), 137-143 (2000).

    4. Radwan, H.S.A., Riskallah, M.R., and El-Keie, I.A. Synergistic effects on the toxicity of organotins on cotton leafworms. Toxicology 14(3), 193-198 (1979).