An antagonist of NPY receptor Y5
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Velneperit

Item No. 33850

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[[(1,1-dimethylethyl)sulfonyl]amino]-N-[5-(trifluoromethyl)-2-pyridinyl]-cyclohexanecarboxamide
CAS Number
342577-38-2
Synonyms
  • S-2367
Molecular Formula
C17H24F3N3O3S
Formula Weight
407.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
244, 279 nm
SMILES
FC(F)(F)C(C=N1)=CC=C1NC([C@H]2CC[C@@H](CC2)NS(C(C)(C)C)(=O)=O)=O
InChi Code
InChI=1S/C17H24F3N3O3S/c1-16(2,3)27(25,26)23-13-7-4-11(5-8-13)15(24)22-14-9-6-12(10-21-14)17(18,19)20/h6,9-11,13,23H,4-5,7-8H2,1-3H3,(H,21,22,24)/t11-,13-
InChi Key
WGEWUYACXPEFPO-AULYBMBSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $104

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    10 mg

    $185

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    25 mg

    $409

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Velneperit is a nonpeptide antagonist of neuropeptide Y (NPY) receptor Y5 (Ki = 5.3 nM).1 It is selective for Y5 over Y1, Y2, and Y4 receptors, as well as a panel of 44 receptors, ion channels, transporters and enzymes, at 10 µM. Velneperit inhibits NPY-induced decreases in forskolin-induced cAMP production in CHO-K1 cells expressing the human Y5 receptor (IC50 = 169 nM). In vivo, velneperit (50 mg/kg) suppresses Y5 agonist-induced increases in food intake in high-fat diet-induced obese (DIO) mice. It also reduces body weight gain and suppresses food intake in DIO mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fukasaka, Y., Nambu, H., Tanioka, H., et al. An insurmountable NPY Y5 receptor antagonist exhibits superior anti-obesity effects in high-fat diet-induced obese mice. Neuropeptides 70, 55-63 (2018).