An NRP-1 antagonist
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EG 00229 (trifluoroacetate salt)

Item No. 33937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[[3-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine, 2,2,2-trifluoroacetate
CAS Number
1210945-69-9
Molecular Formula
C17H19N7O5S3 • CF3COOH
Formula Weight
611.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 40 mg/ml
SMILES
OC(C(F)(F)F)=O.N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(NS(=O)(C2=CC=CC3=NSN=C32)=O)C=CS1)=O
InChi Code
InChI=1S/C17H19N7O5S3.C2HF3O2/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-30-14)24-32(28,29)12-5-1-3-9-13(12)23-31-22-9;3-2(4,5)1(6)7/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20);(H,6,7)/t11-;/m0./s1
InChi Key
ZYQBITUOSRZDTG-MERQFXBCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $46

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    5 mg

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    10 mg

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    25 mg

    $662

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    Cayman Chemical
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    Product Description

    EG 00229 is an antagonist of neuropilin-1 (NRP-1).1 It inhibits the binding of VEGF-A to porcine aortic endothelial cells expressing NRP-1, but not VEGFR2, with an IC50 value of 8 µM. EG 00229 (100 µM) reduces VEGF-A-induced migration of human umbilical vein endothelial cells (HUVECs) and enhances the cytotoxicity of paclitaxel (Item No. 10461) or 5-fluorouracil (Item No. 14416) in A549 lung cancer cells. It also reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity in Caco-2 cells when used at a concentration of 100 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jarvis, A., Allerston, C.K., Jia, H., et al. Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J. Med. Chem. 53(5), 2215-2226 (2010).

    2. Daly, J.L., Simonetti, B., Klein, K., et al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370(6518), 861-865 (2020).