A metabolite of netupitant
Related Products
Parent Compound(s)
23809Netupitant
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Netupitant N-oxide

Item No. 34005

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,α,α-trimethyl-N-[6-(4-methyl-4-oxido-1-piperazinyl)-4-(2-methylphenyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-benzeneacetamide
CAS Number
910808-11-6
Molecular Formula
C30H32F6N4O2
Formula Weight
594.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly, heatedMethanol: slightly soluble
SMILES
O=C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C2=CN=C(N3CC[N+](C)(CC3)[O-])C=C2C4=C(C)C=CC=C4
InChi Code
InChI=1S/C30H32F6N4O2/c1-19-8-6-7-9-23(19)24-17-26(39-10-12-40(5,42)13-11-39)37-18-25(24)38(4)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3
InChi Key
FKUOVQVMCOPBJS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $69

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    5 mg

    $214

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    10 mg

    $363

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    Product Description

    Netupitant N-oxide is a metabolite of the neurokinin-1 (NK1) receptor antagonist netupitant (Item No. 23809).1 Netupitant N-oxide is formed from netupitant by the cytochrome P450 (CYP) isoform CYP3A4.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lanzarotti, C., and Rossi, G. Effect of netupitant, a highly selective NK1 receptor antagonist, on the pharmacokinetics of midazolam, erythromycin and dexamethasone. Support Care Cancer 21(10), 2783-2791 (2013).