An inhibitor of arginase and p70S6K1
Related Products
Isomer(s)
38709L-Valine
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L-Norvaline

Item No. 34029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
6600-40-4
Synonyms
  • α-L-Aminopentanoic Acid
  • L-Nva
  • NSC 203786
Molecular Formula
C5H11NO2
Formula Weight
117.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
CCC[C@H](N)C(O)=O
InChi Code
InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChi Key
SNDPXSYFESPGGJ-BYPYZUCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $63

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    25 g

    $110

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    100 g

    $268

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    Product Description

    L-Norvaline is a non-proteinogenic amino acid, an isomer of valine, and an inhibitor of arginase and p70 ribosomal S6 kinase 1 (p70S6K1) kinase.1,2 It inhibits arginase-mediated urea production in J774A.1 macrophage lysates when used at a concentration of 10 mM and TNF-α-induced p70S6K1 activation in human umbilical vein endothelial cells (HUVECs) at 20 mM.1 L-Norvaline reduces microgliosis and the level of amyloid-β fibrils in the hippocampus, as well as improves learning and memory in the Morris water maze in the 3xTg mouse model of Alzheimer’s disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, C.-I., Liao, J.C., and Kuo, L. Arginase modulates nitric oxide production in activated macrophages. Am. J. Physiol. 274(1), H342-H348 (1998).

    2. Ming, X.-F., Rajapakse, A.G., Carvas, J.M., et al. Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. BMC Cardiovasc. Disord. 9, 12 (2009).

    3. Polis, B., Srikanth, K.D., Elliott, E., et al. L-Norvaline reverses cognitive decline and synaptic loss in a murine model of Alzheimer’s disease. Neurotherapeutics 15(4), 1036-1054 (2018).