An oleanane-type triterpenoid with diverse biological activities
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Isomer(s)
34130Zingibroside R1
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Chikusetsusaponin IVa

Item No. 34832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl β-D-glucopyranosiduronic acid
CAS Number
51415-02-2
Synonyms
  • Chikusetsu Saponin IVa
  • Chi IVa
Molecular Formula
C42H66O14
Formula Weight
795.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC([C@]23[C@](CC(C)(CC3)C)([H])C4=CC[C@@]([C@@]5([C@@](C(C)([C@H](CC5)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)C)([H])CC7)C)([H])[C@]7(C)[C@@]4(CC2)C)=O
InChi Code
InChI=1S/C42H66O14/c1-37(2)14-16-42(36(52)56-34-30(48)27(45)26(44)22(19-43)53-34)17-15-40(6)20(21(42)18-37)8-9-24-39(5)12-11-25(38(3,4)23(39)10-13-41(24,40)7)54-35-31(49)28(46)29(47)32(55-35)33(50)51/h8,21-32,34-35,43-49H,9-19H2,1-7H3,(H,50,51)/t21-,22+,23-,24+,25-,26+,27-,28-,29-,30+,31+,32-,34-,35+,39-,40+,41+,42-/m0/s1
InChi Key
YOSRLTNUOCHBEA-SGVKAIFKSA-N
Origin
Plant/Panax pseudoginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    50 mg

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    Product Description

    Chikusetsusaponin IVa is an oleanane-type triterpenoid that has been found in P. stipuleanatus and has diverse biological activities.1,2,3 It inhibits the growth of human HL-60 leukemia and HCT116 colon cancer cells (IC50s = 76.23 and 78.11 µM, respectively).1 Chikusetsusaponin IVa (50-200 µg/ml) reduces LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, IL-1β, IL-6, and TNF-α levels in THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).2 It decreases plasma glucose, triglyceride, and LDL-cholesterol, and increases HDL-cholesterol, levels in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104) and a high-fat diet when administered at doses ranging from 45 to 180 mg/kg.3 It also decreases malondialdehyde (MDA), and increases superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase 4 (GPX4), levels in the pancreas in the same model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, C., Ding, Y., Nguyen, H.T., et al. Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities. Bioorg. Med. Chem. Lett. 20(23), 7110-7115 (2010).

    2. Wang, H., Qi, J., Li, L., et al. Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells. Int. J. Immunopathol. Pharmacol. 28(3), 308-317 (2015).

    3. Wang, L., Duan, J., Jia, N., et al. IRS-2/Akt/GSK-3β/Nrf2 pathway contributes to the protective effects of Chikusetsu Saponin IVa against lipotoxicity. Oxid. Med. Cell. Longev. 8832318 (2021).