An ellagitannin with diverse biological activities
Related Products
Isomer(s)
19196Syringic Acid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ethyl Gallate

Item No. 34193

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4,5-trihydroxy-benzoic acid, ethyl ester
CAS Number
831-61-8
Synonyms
  • Ethyl 3,4,5-trihydroxybenzoate
  • Gallic Acid
  • NSC 402626
  • Phyllemblin
Molecular Formula
C9H10O5
Formula Weight
198.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
220, 276 nm
SMILES
O=C(C1=CC(O)=C(C(O)=C1)O)OCC
InChi Code
InChI=1S/C9H10O5/c1-2-14-9(13)5-3-6(10)8(12)7(11)4-5/h3-4,10-12H,2H2,1H3
InChi Key
VFPFQHQNJCMNBZ-UHFFFAOYSA-N
Origin
Semi-synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 g

    $69

    Add

    100 g

    $120

    Add

    250 g

    $248

    Add

    500 g

    $297

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Ethyl gallate is an ellagitannin that has been found in A. nilotica and has diverse biological activities.1,2,3,4,5 It inhibits squalene epoxidase with an IC50 value of 4.2 µM for the rat enzyme.1 Ethyl gallate scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 4.96 µg/ml).2 It inhibits the proliferation of, and induces apoptosis in, HL-60 leukemia cells when used at a concentration of 100 µM.3 Ethyl gallate is also active against the Gram-negative bacterium M. catarrhalis (IC50 = 1.15 µg/ml).4 It reverses decreases in mean arterial blood pressure (MAP) and systemic vascular resistance in a dog model of E. coli-induced septic shock when administered at a dose of 80 mg/kg.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abe, I., Kashiwagi, Y., Noguchi, H., et al. Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J. Nat. Prod. 64(8), 1010-1014 (2001).

    2. Kalaivani, T., Rajasekaran, C., and Mathew, L. Free radical scavenging, cytotoxic, and hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia nilotica (L.) Wild. Ex. Delile subsp. indica (Benth.) Brenan. J. Food Sci. 76(6), T144-T149 (2011).

    3. Kim, W.-H., Song, H.-O., Choi, H.-J., et al. Ethyl gallate induces apoptosis of HL-60 cells by promoting the expression of caspases-8, -9, -3, apoptosis-inducing factor and endonuclease G. Int. J. Mol. Sci. 13(9), 11912-11922 (2012).

    4. Cueva, C., Mingo, S., Muñoz-González, I., et al. Antibacterial activity of wine phenolic compounds and oenological extracts against potential respiratory pathogens. Lett. Appl. Microbiol. 54(6), 557-563 (2012).

    5. Mink, S.N., Jacobs, H., Gotes, J., et al. Ethyl gallate, a scavenger of hydrogen peroxide that inhibits lysozyme-induced hydrogen peroxide signaling in vitro, reverses hypotension in canine septic shock. J. Appl. Physiol. 110(2), 359-374 (2011).