A protein tyrosine phosphatase inhibitor
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Sodium Orthovanadate

Item No. 34328

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
sodium vanadium oxide
CAS Number
13721-39-6
Synonyms
  • NSC 79534
Molecular Formula
Na3O4V
Formula Weight
183.9
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: Slightly soluble
SMILES
O=[V]([O-])([O-])[O-].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/3Na.4O.V/q3*+1;;3*-1;
InChi Key
IHIXIJGXTJIKRB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $36

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    50 g

    $153

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    100 g

    $288

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    250 g

    $462

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Sodium orthovanadate is a protein tyrosine phosphatase inhibitor.1,2,3,4 It inhibits autocrine growth of A549 lung, A498 kidney, and DU145 prostate cancer cells when used at concentrations ranging from 1 to 20 µM.1 Sodium orthovanadate (20 mg/kg) protects mice from radiation-induced hematopoietic and gastrointestinal syndromes.2 It reduces postprandial glucose levels and increases glucose tolerance in a rat model of diabetes induced by streptozotocin (Item No. 13104) when administered ad libitum in drinking water at a concentration of 0.5 mg/ml.3 Sodium orthovanadate also decreases total and cortical infarct size in a rat model of ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klein, A., Holko, P., Ligeza, J., et al. Sodium orthovanadate affects growth of some human epithelial cancer cells (A549, HTB44, DU145). Folia Biol. (Kraków) 56(3-4), 115-121 (2008).

    2. Wang, B., Tanaka, K., Morita, A., et al. Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice. J. Radiat. Res. 54(4), 620-629 (2013).

    3. Brichard, S.M., Okitolonda, W., and Henquin, J.C. Long term improvement of glucose homeostasis by vanadate treatment in diabetic rats. Endocrinology 123(4), 2048-2053 (1988).

    4. Hasegawa, Y., Hamada, J.-I., Morioka, M., et al. Neuroprotective effect of postischemic administration of sodium orthovanadate in rats with transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 23(9), 1040-1051 (2003).