A TAAR1 antagonist
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EPPTB

Item No. 34330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)-benzamide
CAS Number
1110781-88-8
Synonyms
  • Ro 5212773
Molecular Formula
C20H21F3N2O2
Formula Weight
378.4
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
λmax
290 nm
SMILES
O=C(C1=CC=C(N2CCCC2)C(C(F)(F)F)=C1)NC3=CC(OCC)=CC=C3
InChi Code
InChI=1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26)
InChi Key
KLFVWQCQUXXLOU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $102

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    25 mg

    $238

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    Product Description

    EPPTB is an antagonist of trace amine-associated receptor 1 (TAAR1; Ki = 0.9 nM for the mouse receptor).1 It selectively inhibits β-phenylethylamine-induced cAMP production in HEK293 cells expressing mouse TAAR1 over human or rat TAAR1 (IC50s = 27.5, 7,487, and 4,539 nM, respectively). EPPTB (10 nM) reduces decreases in the firing frequency of dopaminergic neurons induced by p-tyramine (Item No. 18601) in mouse ventral tegmental area (VTA) slices when used at a concentration of 10 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bradaia, A., Trube, G., Stalder, H., et al. The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc. Natl. Acad. Sci. USA 106(47), 20081-20086 (2009).