A multivalent ionizable cationic lipid
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GL67

Item No. 34371

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-[(3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate] cholest-5-en-3-ol
CAS Number
179075-30-0
Synonyms
  • N4-Spermine Cholesteryl Carbamate
Molecular Formula
C38H70N4O2
Formula Weight
615.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(N(CCCN)CCCCNCCCN)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C38H70N4O2/c1-28(2)11-8-12-29(3)33-15-16-34-32-14-13-30-27-31(17-19-37(30,4)35(32)18-20-38(33,34)5)44-36(43)42(26-10-22-40)25-7-6-23-41-24-9-21-39/h13,28-29,31-35,41H,6-12,14-27,39-40H2,1-5H3/t29-,31+,32+,33-,34+,35+,37+,38-/m1/s1
InChi Key
KBBLYWGVXTZWCU-HMVYLTCSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $261

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    Cayman Chemical
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    Product Description

    GL67 is a multivalent ionizable cationic lipid composed of spermine (Item No. 18041) conjugated to cholesterol (Item No. 9003100).1 It has been used in the generation of liposomes complexed with plasmid DNA for use in vitro and in vivo. GL67 has also been used in combination with DC-Chol (Item No. 16943) and 1,2-dioloeyl-sn-glycero-3-PE (1,2-DOPE; Item No. 15091) in the generation of lipid nanocarriers for the delivery of siRNA to A549 lung cancer cells.2 GL67-containing liposomes, in complex with plasmid DNA for the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), leads to the expression of functional wild-type CFTR in HEK293 cells.3 Aerosol administration of GL67-containing liposomes, in complex with plasmid DNA for the gene encoding CFTR, increases trachea and whole lung mRNA levels of CFTR.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Andries, O., De Filette, M., Rejman, J., et al. Comparison of the gene transfer efficiency of mRNA/GL67 and pDNA/GL67 complexes in respiratory cells. Mol. Pharm. 9(8), 2136-2145 (2012).

    2. Jarallah, S.J., Aldossary, A.M., Tawfik, E.A., et al. GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells. Saudi Pharm. J. 31(7), 1139-1148 (2023).

    3. Hyde, S.C., Pringle, I.A., Abdullah, S., et al. CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression. Nat. Biotechnol. 26(5), 549-551 (2008).