A flavonoid glycoside with diverse biological activities
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Nepitrin

Item No. 34387

Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-7-(β-D-glucopyranosyloxy)-5-hydroxy-6-methoxy-4H-1-benzopyran-4-one
CAS Number
569-90-4
Synonyms
  • 6-methoxy Luteolin-7-glucoside
  • Nepetin 7-O-glucoside
Molecular Formula
C22H22O12
Formula Weight
Purity
≥95%
A solid
λmax
258, 272, 350 nm
SMILES
OC1=C2C(OC(C3=CC(O)=C(C=C3)O)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1OC
InChi Code
InChI=1S/C22H22O12/c1-31-21-14(33-22-20(30)19(29)17(27)15(7-23)34-22)6-13-16(18(21)28)11(26)5-12(32-13)8-2-3-9(24)10(25)4-8/h2-6,15,17,19-20,22-25,27-30H,7H2,1H3/t15-,17-,19+,20-,22-/m1/s1
InChi Key
DMXHXBGUNHLMQO-IWLDQSELSA-N
Origin
Plant/Salvia plebeia
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Nepitrin is a flavonoid glycoside that has been found in S. plebeia and has diverse biological activities.1,2,3 It protects lard from thermal oxidation when used at concentrations of 0.02 and 0.04%. Nepitrin inhibits carrageenin-induced edema and yeast-induced fever in rats.2 It decreases serum levels of triglycerides and LDL, as well as increases serum HDL levels, in a rat model of high-fat diet-induced atherosclerosis when administered at doses of 20 and 50 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weng, X.C., and Weng, W. Antioxidant activity of compounds isolated from Salvia plebia. Food Chem. 71(4), 489-493 (2000).

    2. Agarwal, O.P. The anti-inflammatory action of nepitrin, a flavonoid. Agents Actions 12(3), 298-302 (1982).

    3. Devi, S., Rangra, N.K., Rawat, R., et alAnti-atherogenic effect of Nepitrin-7-O-glucoside: A flavonoid isolated from Nepeta hindostana via acting on PPAR - α receptor. Steroids 165, 108770 (2021).