An internal standard for the quantification of N-desmethyl ivabradine
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rac-N-desmethyl Ivabradine-d6 (hydrochloride)

Item No. 34513

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-[[(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]amino]propyl-1,1,2,2,3,3-d6]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride
CAS Number
2804269-05-2
Molecular Formula
C26H28D6N2O5 • HCl
Formula Weight
497.1
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
COC1=CC(CCN2C([2H])([2H])C([2H])([2H])C([2H])([2H])NC[C@@H]3C4=CC(OC)=C(C=C4C3)OC)=C(CC2=O)C=C1OC.Cl
InChi Code
InChI=1S/C26H34N2O5.ClH/c1-30-22-11-17-6-9-28(26(29)14-18(17)12-23(22)31-2)8-5-7-27-16-20-10-19-13-24(32-3)25(33-4)15-21(19)20;/h11-13,15,20,27H,5-10,14,16H2,1-4H3;1H/t20-;/m1./s1/i5D2,7D2,8D2;
InChi Key
MIIIKWNQFDQJGS-OTVKAUOOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $602

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    Product Description

    rac-N-desmethyl Ivabradine-d6 is intended for use as an internal standard for the quantification of N-desmethyl ivabradine (Item No. 27808) by GC- or LC-MS. N-desmethyl Ivabradine is an active metabolite of ivabradine (Item No. 15868).1 Ivabradine is metabolized by the cytochrome P450 (CYP) isoform CYP3A4.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rosa, G.M., Ferrero, S., Ghione, P., et al. An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure. Expert Opin. Drug Metab. Toxicol. 10(2), 279-291 (2014).