A niacin receptor agonist
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Acifran

Item No. 34556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
CAS Number
72420-38-3
Synonyms
  • (±)-Acifran
Molecular Formula
C12H10O4
Formula Weight
218.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 100 mM
SMILES
O=C1C(C2=CC=CC=C2)(C)OC(C(O)=O)=C1
InChi Code
InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
InChi Key
DFDGRKNOFOJBAJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $102

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    10 mg

    $172

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    25 mg

    $388

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Acifran is a niacin receptor agonist.1,2 It binds to hydroxycarboxylic acid receptor 2 (HCA2), known previously as G protein-coupled receptor 109A (GPR109A) and niacin receptor 1, with an IC50 value of 1.12 µM, as well as induces ERK1/2 phosphorylation in CHO-K1 cells expressing HCA2 or HCA3, also known as GPR109B and niacin receptor 2 , when used at concentrations ranging from 0.01 to 10 µM. Acifran (1 mg/kg) reduces serum triglyceride and LDL levels and increases the ratio of HDL to total cholesterol in hyperlipidemic rats.3 It also reduces serum triglyceride levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wise, A., Foord, S.M., Fraser, N.J., et al. Molecular identification of high and low affinity receptors for nicotinic acid. The Journal of Biological Chemisty 278(11), 9869-9874 (2003).

    2. Mahboubi, K., Witman-Jones, T., Adamus, J.E., et al. Triglyceride modulation by acifran analogs: Activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74. Biochem. Biophys. Res. Commun. 340(2), 482-490 (2006).

    3. Cayen, M.N., Kallai-Sanfacon, M.A., Dubuc, J., et al. Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 45(3), 267-279 (1982).