An internal standard for the quantification of capsaicin
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(E/Z)-Capsaicin-d3

Item No. 34695

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-hydroxy-3-(methoxy-d3)phenyl]methyl]-8-methyl-6-nonenamide
CAS Number
1185237-43-7
Molecular Formula
C18H24D3NO3
Formula Weight
308.4
Purity
≥98% (mixture of isomers)
Formulation (Request formulation change)
A 5 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: solubleDMF: solubleDMSO: solubleEthyl Acetate: solubleMethanol: soluble
SMILES
CC(C)/C=C/CCCCC(NCC1=CC(OC([2H])([2H])[2H])=C(C=C1)O)=O
InChi Code
InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+/i3D3
InChi Key
YKPUWZUDDOIDPM-HPFTVYJYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Capsaicin-d3 is intended for use as an internal standard for the quantification of capsaicin (Item Nos. 92350 | 10010743) by GC- or LC-MS. Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.1,2,3,4 It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.1 Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.2 Capsaicin induces substance P (Item No. 24035) release in rat spinal cord slices with an EC50 value of 2.3 µM.3 It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).4 Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.

    WARNING This product is not for human or veterinary use.