An internal standard for the quantification of pitavastatin lactone
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Unlabeled Version(s)
21785Pitavastatin lactone
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Pitavastatin lactone-d4

Item No. 34696

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6S-((E)-2-(2-cyclopropyl-4-(4-fluorophenyl-2,3,5,6-d4)quinolin-3-yl)vinyl)-4R-hydroxytetrahydro-2H-pyran-2-one
Molecular Formula
C25H18D4FNO3
Formula Weight
407.5
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
λmax
245 nm
SMILES
FC1=C([2H])C([2H])=C(C2=C(/C=C/[C@@H]3C[C@@H](O)CC(O3)=O)C(C4CC4)=NC5=C2C=CC=C5)C([2H])=C1[2H]
InChi Code
InChI=1S/C25H22FNO3/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-19-13-18(28)14-23(29)30-19/h1-4,7-12,16,18-19,28H,5-6,13-14H2/b12-11+/t18-,19-/m1/s1/i7D,8D,9D,10D
InChi Key
XJVKVAFYQRWVAJ-FZVTUHSMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $197

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    1 mg

    $374

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    5 mg

    $1,084

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Pitavastatin lactone-d4 is intended for use as an internal standard for the quantification of pitavastatin lactone (Item No. 21785) by GC- or LC-MS. Pitavastatin lactone is a major phase 2 metabolite of the HMG-CoA reductase inhibitor pitavastatin (Item No. 15414).1,2 Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyltransferase (UGT) isoforms UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be retroconverted to pitavastatin via hydrolysis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fujino, H., Yamada, I., Shimada, S., et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: Human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica 33(1), 27-41 (2003).

    2. Aoki, T., Nishimura, H., Nakagawa, S., et al. Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung 47(8), 904-909 (1997).