A CCK1 receptor antagonist
Related Products
Isomer(s)
25534Loxiglumide
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Dexloxiglumide

Item No. 34759

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-pentanoic acid
CAS Number
119817-90-2
Molecular Formula
C21H30Cl2N2O5
Formula Weight
461.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/ml, sonicated
SMILES
CCCCCN(CCCOC)C([C@@H](CCC(O)=O)NC(C1=CC(Cl)=C(C=C1)Cl)=O)=O
InChi Code
InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)/t18-/m1/s1
InChi Key
QNQZBKQEIFTHFZ-GOSISDBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $36

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    25 mg

    $81

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    Product Description

    Dexloxiglumide is a cholecystokinin (CCK) receptor antagonist and is the single (R) isomer of loxiglumide (Item No. 25534).1,2 It selectively binds to the CCK1 receptor over CCK2 in CHO cells expressing the rat receptors (Kis = 0.0234 and 5.88 µM, respectively).1 Dexloxiglumide (20 µmol/kg) inhibits guinea pig gallbladder contractions induced by the CCK agonist CCK octapeptide (sulfated) (CCK-8S; Item No. 23371). It reduces CCK-8-induced gastric emptying in rats (ID50 = 1.14 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morton, M.F., Barrett, T.D., Yan, W., et al. 3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a novel, potent, and selective cholecystokinin 1 receptor antagonist: In vitro and in vivo pharmacological comparison with dexloxiglumide. J. Pharmacol. Exp. Ther. 323(2), 562-569 (2007).

    2. Scarpignato, C., Kisfalvi, I., D'Amato, M., et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: Evaluation of their receptor selectivity in vivo. Aliment. Pharmacol. Ther. 10(3), 411-419 (1996).