A coumarin with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

3-Hydroxycoumarin

Item No. 34815

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-2H-1-benzopyran-2-one
CAS Number
939-19-5
Synonyms
  • 3-Coumarinol
  • NSC 74691
Molecular Formula
C9H6O3
Formula Weight
162.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
230, 309 nm
SMILES
O=C1OC2=C(C=C1O)C=CC=C2
InChi Code
InChI=1S/C9H6O3/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5,10H
InChi Key
MJKVTPMWOKAVMS-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $57

    Add

    5 g

    $266

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    3-Hydroxycoumarin is a coumarin that has been found in A. reinwardtii and has diverse biological activities.1,2,3 It inhibits 15-lipoxygenase-1 (15-LO-1; IC50 = 9.5 µM).1 3-hydroxycoumarin scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 0.61 mM) and inhibits lipid peroxidation in vitro (IC50 = 69.07 mM).2 It is protective against UVB-induced embryotoxicity in sea urchins (E. lucunter).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alavi, S.J., Sadeghian, H., Seyedi, S.M., et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem. Biol. Drug Des. 91(6), 1125-1132 (2017).

    2. Rattanapan, J., Sichaem, J., and Tip-pyang, S. Chemical constituents and antioxidant activity from the stems of Alyxia reinwardtii. Rec. Nat. Prod. 6(3), 288-291 (2012).

    3. de Araujo Leite, J.C., de Castro, T.M.X., Barbosa-Filho, J.M., et al. Photoprotective effect of coumarin and 3-hydroxycoumarin in sea urchin gametes and embryonic cells. J. Photochem. Photobiol. B Biol. 146, 44-51 (2015).