An inactive analog of U-0126
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U-0124

Item No. 34871

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-bis[amino(methylthio)methylene]-butanedinitrile
CAS Number
108923-79-1
Molecular Formula
C8H10N4S2
Formula Weight
226.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightlyMethanol: slightly
SMILES
N#CC(C(C#N)=C(N)SC)=C(N)SC
InChi Code
InChI=1S/C8H10N4S2/c1-13-7(11)5(3-9)6(4-10)8(12)14-2/h11-12H2,1-2H3
InChi Key
LBQNBMSPTURKGS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $95

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    1 mg

    $167

    Add
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    Product Description

    U-0124 is an inactive analog of the MEK inhibitor and AMPK activator U-0126 (Item No. 70970) that has been used as a negative control for the kinase activity of MEK.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Favata, M.F., Horiuchi, K.Y., Manos, E.J., et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. The Journal of Biological Chemisty 273(29), 18623-18632 (1998).

    2. Zipperly, M.E., Sultan, F.A., Graham, G.-E., et al. Regulation of dopamine-dependent transcription and cocaine action by Gadd45b. Neuropsychopharmacology 46(4), 709-720 (2021).