A methylated derivative of L-tryptophan
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L-Abrine

Item No. 34914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-L-tryptophan
CAS Number
526-31-8
Synonyms
  • NPLC 0233
  • N-Methyltryptophan
  • N-methyl-L-Tryptophan
Molecular Formula
C12H14N2O2
Formula Weight
218.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: SolubleWater: Soluble
SMILES
OC([C@H](NC)CC1=CNC2=CC=CC=C21)=O
InChi Code
InChI=1S/C12H14N2O2/c1-13-11(12(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,13-14H,6H2,1H3,(H,15,16)/t11-/m1/s1
InChi Key
CZCIKBSVHDNIDH-LLVKDONJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $54

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    50 mg

    $86

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    100 mg

    $108

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    250 mg

    $216

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    Product Description

    L-Abrine is a methylated derivative of the essential amino acid L-tryptophan (Item No. 29600). It promotes growth in rats fed a tryptophan-deficient diet.1 Unlike tryptophan, L-abrine does not affect sleep or wakefulness in rats.2 Serum levels of L-abrine are decreased in patients after an acute ischemic stroke.3 Increased urine levels of L-abrine have been used as a biomarker for abrin poisoning.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gordon, W.G., and Jackson, R.W. The metabolism of certain monomethyltryptophanes. The Journal of Biological Chemisty 110(1), 151-164 (1935).

    2. Miletich, R.S., Djuricic-Nedelson, M., and Radulovacki, M. Tryptophan analogues and sleep in rats. Research Communications in Psychology, Psychiatry & Behavior 8(3), 235-241 (1983).

    3. Qi, B., Zhang, Y., Xu, B., et al. Metabolomic characterization of acute ischemic stroke facilitates metabolomic biomarker discovery. Appl. Biochem. Biotechnol. 194(11), 5443-5455 (2022).

    4. Wooten, J.V., Pittman, C.T., Blake, T.A., et al. A case of abrin toxin poisoning, confirmed via quantitation of L-abrine (N-methyl-L-tryptophan) biomarker. J. Med. Toxicol. 10(4), 392-394 (2014).