The immediate precursor of melatonin
Related Products
Analytical Standard(s)
33681N-Acetylserotonin
Isomer(s)
333131-methyl-L-Tryptophan 34914L-Abrine
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

N-Acetylserotonin

Item No. 14535

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-acetamide
CAS Number
1210-83-9
Synonyms
  • N-Acetyl-5-hydroxytryptamine
  • NAS
Molecular Formula
C12H14N2O2
Formula Weight
218.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 12.5 mg/mlEthanol: 10 mg/ml
λmax
224, 278 nm
SMILES
OC1=CC=C(NC=C2CCNC(C)=O)C2=C1
InChi Code
InChI=1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15)
InChi Key
MVAWJSIDNICKHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $41

    Add

    100 mg

    $75

    Add

    250 mg

    $178

    Add
    Product Description

    N-Acetylserotonin (NAS) is the immediate precursor of melatonin (Item No. 14427). It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to melatonin by acetylserotonin O-methyltransferase.1 Like melatonin, NAS is considered to be a neurotransmitter and acts as an agonist at the melatonin receptors MT1, MT2, and MT3.2 NAS may also have unique central effects since it is distributed in specific brain areas separate from serotonin and melatonin.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chattoraj, A., Liu, T., Zhang, L.S., et al. Melatonin formation in mammals: In vivo perspectives. Rev. Endocr. Metab. Disord. 10(4), 237-243 (2009).

    2. Jang, S.W., Liu, X., Pradoldej, S., et al. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc. Natl. Acad. Sci. USA 107(8), 3876-3881 (2010).