An IDO inhibitor
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1-methyl-L-Tryptophan

Item No. 33313

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
21339-55-9
Synonyms
  • NSC 77678
  • L-1-Methyltryptophan
  • 1-L-MT
  • L-1MT
Molecular Formula
C12H14N2O2
Formula Weight
218.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Aqueous acid: 10 mg/ml
λmax
223 nm
SMILES
OC([C@@H](N)CC1=CN(C)C2=CC=CC=C12)=O
InChi Code
InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1
InChi Key
ZADWXFSZEAPBJS-JTQLQIEISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    1-methyl-L-Tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 19 µM).1 It inhibits kynurenine production from primary human monocyte-derived IDO-positive dendritic cells and increases T cell proliferation in an allogeneic mixed lymphocyte reaction (allo-MLR) when used at a concentration of 100 µM. 1-methyl-L-Tryptophan reverses depressive-like behavior in mice in a Bacillus Calmette-Guerin inflammation-induced model of depression.2 Unlike 1-methyl-D-tryptophan, 1-methyl-L-tryptophan does not have an additive effect on survival induced by cyclophosphamide (Item No. 13849) in an orthotopic murine mammary carcinoma model of 4T1 tumors when administered at a dose of 400 mg/kg twice per day.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hou, D.-Y., Muller, A.J., Sharma, M.D., et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res. 67(2), 792-801 (2007).

    2. Rana, P., Sharma, A.K., Jain, S., et al. Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice. J. Basic Clin. Physiol. Pharmacol. 27(6), 569-576 (2016).