A metabolite of macitentan
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Parent Compound(s)
23304Macitentan
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ACT-373898

Item No. 34916

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[5-(4-bromophenyl)-6-[[(propylamino)sulfonyl]amino]-4-pyrimidinyl]oxy]-acetic acid
CAS Number
1433875-14-9
Molecular Formula
C15H17BrN4O5S
Formula Weight
445.3
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
257 nm
SMILES
O=C(COC1=C(C2=CC=C(C=C2)Br)C(NS(=O)(NCCC)=O)=NC=N1)O
InChi Code
InChI=1S/C15H17BrN4O5S/c1-2-7-19-26(23,24)20-14-13(10-3-5-11(16)6-4-10)15(18-9-17-14)25-8-12(21)22/h3-6,9,19H,2,7-8H2,1H3,(H,21,22)(H,17,18,20)
InChi Key
IMSGHDWVBCDHNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $215

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    25 mg

    $437

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    Cayman Chemical
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    Product Description

    ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETB dual antagonist macitentan (Item No. 23304).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dingemanse, J., Sidharta, P.N., Maddrey, W.C., et al. Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. Expert Opin. Drug Saf. 13(3), 391-405 (2013).