An active metabolite of ranolazine
Related Products
Parent Compound(s)
15604Ranolazine (hydrochloride)
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CVT-2738

Item No. 35003

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,6-dimethylphenyl)-1-piperazineacetamide
CAS Number
5294-61-1
Molecular Formula
C14H21N3O
Formula Weight
247.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/ml
SMILES
O=C(CN1CCNCC1)NC2=C(C)C=CC=C2C
InChi Code
InChI=1S/C14H21N3O/c1-11-4-3-5-12(2)14(11)16-13(18)10-17-8-6-15-7-9-17/h3-5,15H,6-10H2,1-2H3,(H,16,18)
InChi Key
NJKRFQIWDJSYOK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $36

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    500 mg

    $68

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    1 g

    $123

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    5 g

    $535

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    Product Description

    CVT-2738 is an active metabolite of the antianginal agent ranolazine (Item No. 15604).1 It is formed from ranolazine by the cytochrome P450 (CYP) isoform CYP3A. CVT-2738 (100 mg/kg) inhibits increases in T-wave height and the RR interval in a mouse model of myocardial ischemia induced by isoprenaline (isoproterenol; Item No. 15592).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Y., Chen, X., Sun, Z., et al. Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasma. J. Chromatogr. B 889-890, 10-16 (2012).

    2. Yao, Z., Gong, S., Guan, T., et al. Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities. Chem. Pharm. Bull. (Tokyo) 57(11), 1218-1222 (2009).