A polyethylene alkyne with diverse biological activities
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Atractylodin

Item No. 35033

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(1E,7E)-1,7-nonadiene-3,5-diyn-1-yl-furan
CAS Number
55290-63-6
Synonyms
  • Atractydin
Molecular Formula
C13H10O
Formula Weight
182.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/mlEthanol: 10 mg/ml
λmax
214, 259, 273, 335, 355 nm
SMILES
C/C=C/C#CC#C/C=C/C1=CC=CO1
InChi Code
InChI=1S/C13H10O/c1-2-3-4-5-6-7-8-10-13-11-9-12-14-13/h2-3,8-12H,1H3/b3-2+,10-8+
InChi Key
GRBKWAXRYIITKG-QFMFQGICSA-N
Origin
Plant/Atractylodes lancea
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $125

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    25 mg

    $294

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    50 mg

    $556

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    Cayman Chemical
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    Product Description

    Atractylodin is a polyethylene alkyne that has been found in A. lancea and has diverse biological activities.1,2,3,4 It inhibits N-acylethanolamine acid amidase (NAAA; IC50 = 2.81 µM for the human enzyme) and increases levels of the endocannabinoids palmitoyl ethanolamide (Item No. 90350) and oleoyl ethanolamide (Item No. 90265) in LPS-stimulated BV-2 microglial cells when used at a concentration of 10 µM.1 Atractylodin is cytotoxic to CL-6 and HuCC-T1 cholangiocarcinoma cells (IC50s = 41.66 and 38.78 µM, respectively).2 Atractylodin (10 mg/kg) increases the gastric emptying rate in mice, an effect that can be blocked by the growth hormone secretagogue receptor (GHS-R) antagonist (D-Lys3)-GHRP-6 (Item No. 36862).3 It decreases pulmonary edema in a mouse model of LPS-induced acute lung injury when administered at doses of 40 and 80 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, L., Ji, C., Li, Y., et al. Natural potent NAAA inhibitor atractylodin counteracts LPS-induced microglial activation. Front. Pharmacol. 11, 577319 (2020).

    2. Kotawong, K., Chaijaroenkul, W., Muhamad, P., et al. Cytotoxic activities and effects of atractylodin and β-eudesmol on the cell cycle arrest and apoptosis on cholangiocarcinoma cell line. J. Pharmacol. Sci. 136(2), 51-56 (2018).

    3. Bai, Y., Zhao, Y.-H., Xu, J.-Y., et al. Atractylodin induces myosin light chain phosphorylation and promotes gastric emptying through ghrelin receptor. Evid. Based Complement. Alternat. Med. 2186798 (2017).

    4. Tang, F., Fan, K., Wang, K., et al. Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways. J. Pharmacol. Sci. 136(4), 203-211 (2018).